Appropriate Use. The Depo-Provera birth control shot has advantages and disadvantages compared to other types of birth control. While it's convenient and effective, for example, the Depo shot also carries the risk of side effects like irregular bleeding and bone loss. This article looks at some of the pros and cons of using Depo-Provera.When To See a Healthcare Provider. Signs of pregnancy after Depo-Provera ( medroxyprogesterone ) may include missed period, nausea, breast tenderness, and more. Many people are able to get pregnant around 8 to 10 months after their last Depo-Provera shot. Depo-Provera, an injectable birth control method, is more than 99% effective at preventing ...May 2, 2023 · Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight. Depression or other mood changes. Eyesight changes or loss, bulging eyes, or change in how contact lenses feel. A lump in the breast, breast pain or soreness, or nipple discharge. Flu -like signs. One major drawback of Depo-Provera is the continuous or irregular bleeding (spotting) that can sometimes occur during the first year. While this typically occurs during the first few months, it can persist for up to a year or longer for some people. Learn more about this side effect and what you can do if it persists. TEK IMAGE / Getty Images.Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight. Eyesight changes or loss, bulging eyes, or change in how contact lenses feel. A lump in the breast, breast pain or soreness, or nipple discharge. Vaginal itching or discharge.The most common side effects associated with DMPA use are bothersome but benign and typically improve with time or upon discontinuation, including irregular bleeding, weight gain, dizziness, abdominal pain, and anxiety . Occasionally, other side effects do occur and may cause significant distress to the patient.redness of the skin. redness or swelling of the breast. sore on the skin of the breast that does not heal. swelling of the eyelids, face, fingers, lips, hands, feet, or lower legs. tightness in the chest. troubled breathing at rest. troubled breathing or swallowing. vaginal bleeding.Jul 15, 2023 · Warning: Blood Pressure IncreasesTestosterone undecanoate can cause blood pressure (BP) increases that can increase the risk of major adverse cardiovascular events (MACE), including non-fatal myocardial infarction, non-fatal stroke and cardiovascular death. headaches and migraine. hot flashes/night sweats. nausea and vomiting. pain. vaginitis. weight gain. People taking Lupron develop symptoms that are similar to menopause, including hot flashes ...Jan 11, 2023 · Appropriate Use. The Depo-Provera birth control shot has advantages and disadvantages compared to other types of birth control. While it's convenient and effective, for example, the Depo shot also carries the risk of side effects like irregular bleeding and bone loss. This article looks at some of the pros and cons of using Depo-Provera. Common side effects of Depo-Medrol may include: weight gain (especially in your face or your upper back and torso); slow wound healing; muscle pain or weakness; thinning skin, increased sweating; stomach discomfort, bloating; headache; or. changes in your menstrual periods. This is not a complete list of side effects and others may occur.Spotting (light bleeding or brown discharge between periods) Not getting your period at all. About half of people stop getting their period while they’re on the shot (don’t worry, this is totally safe). Other possible side effects include: Nausea. Weight gain. Headaches. Sore breasts. Depression. Feb 3, 2023 · slurred speech. stopping of menstrual bleeding. sudden loss of coordination. sudden, severe weakness or numbness in the arm or leg. sudden, unexplained shortness of breath. swelling of the fingers, hands, feet, or lower legs. troubled breathing at rest. unexpected or excess milk flow from the breasts. Potential side effects of cortisone shots increase with larger doses and repeated use. Side effects can include: Cartilage damage. Death of nearby bone. Joint infection. Nerve damage. Temporary facial flushing. Temporary flare of pain and inflammation in the joint. Temporary increase in blood sugar.Potential side effects of cortisone shots increase with larger doses and repeated use. Side effects can include: Cartilage damage. Death of nearby bone. Joint infection. Nerve damage. Temporary facial flushing. Temporary flare of pain and inflammation in the joint. Temporary increase in blood sugar.When To See a Healthcare Provider. Signs of pregnancy after Depo-Provera ( medroxyprogesterone ) may include missed period, nausea, breast tenderness, and more. Many people are able to get pregnant around 8 to 10 months after their last Depo-Provera shot. Depo-Provera, an injectable birth control method, is more than 99% effective at preventing ...PIP: In Chiang Mai, Thailand, community physicians followed 2422 women who used the contraceptive injectable, Depo-Provera (DMPA), either during pregnancy and/or while breast feeding. They compared the longterm growth of the children exposed to DMPA with that of 1167 children who were not exposed to hormones during pregnancy or lactation.Common side effects of Depo-Estradiol may include: breast pain; headache; vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding; thinning scalp hair; or. nausea, vomiting, bloating, stomach cramps. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side ...Hot flashes (flushing), increased sweating, night sweats, tiredness, headache, upset stomach, breast changes, acne, joint/muscle aches, trouble sleeping, reduced sexual interest, vaginal ...Lupron is a drug doctors prescribe to treat prostate cancer. It works by reducing testosterone levels in the body, slowing cancer growth. Lupron is the brand name for leuprolide acetate. Lupron ...Aug 1, 2023 · lightening of normal skin color. pain, redness, or hard skin at the injection site. pitting or depression of the skin at the injection site. red face. reddish purple lines on the arms, face, legs, trunk, or groin. swelling of the stomach area. thinning of the scalp hair. Other side effects not listed may also occur in some patients. Nov 12, 2020 · This article highlights medroxyprogesterone as it is used as contraception to prevent pregnancy. This activity discusses the mechanism of action, adverse effects, monitoring, and contraindications for medroxyprogesterone. Also, it highlights the important role that providers play in administering medroxyprogesterone and regularly monitoring patients for side effects. altered interest in having sexual intercourse. abnormal bleeding from the uterus. a problem with menstrual periods. dizziness. weight gain. headache. nervousness. reactions at the site of the ...weakness near the injection site; Long-term side effects. Taking steroid shots for a prolonged period of time increases the risk of more serious side effects. Long-term side effects can include:redness of the skin. redness or swelling of the breast. sore on the skin of the breast that does not heal. swelling of the eyelids, face, fingers, lips, hands, feet, or lower legs. tightness in the chest. troubled breathing at rest. troubled breathing or swallowing. vaginal bleeding.So I have been on depo for about two years now and have never had severe problems. I have noticed since starting Depo that I have more vaginal discharge, more acne, and my boobs tend to be sore more often. However, this past week I have noticed an intense increase in some side effects. My boobs are extremely sore and I am having a mixture of ...Spotting (light bleeding or brown discharge between periods) Not getting your period at all. About half of people stop getting their period while they’re on the shot (don’t worry, this is totally safe). Other possible side effects include: Nausea. Weight gain. Headaches. Sore breasts. Depression.Jun 14, 2023 · DEPO-MEDROL is an anti-inflammatory glucocorticoid for intramuscular, intra-articular, soft tissue, or intralesional injection. It is available in three strengths: 20 mg/mL, 40 mg/mL, 80 mg/mL. Sodium Chloride was added to adjust tonicity. When necessary, pH was adjusted with sodium hydroxide and/or hydrochloric acid. Lupron is a drug doctors prescribe to treat prostate cancer. It works by reducing testosterone levels in the body, slowing cancer growth. Lupron is the brand name for leuprolide acetate. Lupron ...The most commonly reported side effects were hot flashes or sweats, gastrointestinal disorders, hyperhidrosis, edema, emotional lability or depression, respiratory disorder, urinary disorder, nausea or vomiting, injection site reaction, joint disorders, testicular atrophy, asthenia, flu syndrome, headache, skin reaction, fatigue, and pain.The use of Depo-Provera CI is not recommended as a long-term (i.e., longer than 2 years) birth control method unless other options are considered inadequate. BMD should be evaluated when a woman needs to continue to use Depo-Provera CI long-term. In adolescents, interpretation of BMD results should take into account patient age and skeletal ... The use of Depo-Provera CI is not recommended as a long-term (i.e., longer than 2 years) birth control method unless other options are considered inadequate. BMD should be evaluated when a woman needs to continue to use Depo-Provera CI long-term. In adolescents, interpretation of BMD results should take into account patient age and skeletal ... Pros No need to take a daily pill. You’ll get a shot once every 12 to 13 weeks. Less opportunity to miss a dose. It’s very common to occasionally miss a daily pill. With a shot, you won’t have...The shots may be doing more harm than good. In a new study published in the journal Radiology, researchers looked at 459 patients in a US hospital who had received one to three corticosteroid ...Jun 16, 2021 · To go off of this form of birth control, just don’t get your next shot. But be aware that your periods and fertility may take more than the initial three months to return. “In some people, it ... Lupron is a drug doctors prescribe to treat prostate cancer. It works by reducing testosterone levels in the body, slowing cancer growth. Lupron is the brand name for leuprolide acetate. Lupron ...Mar 6, 2023 · Lupron is a drug doctors prescribe to treat prostate cancer. It works by reducing testosterone levels in the body, slowing cancer growth. Lupron is the brand name for leuprolide acetate. Lupron ... The use of Depo-Provera CI is not recommended as a long-term (i.e., longer than 2 years) birth control method unless other options are considered inadequate. BMD should be evaluated when a woman needs to continue to use Depo-Provera CI long-term. In adolescents, interpretation of BMD results should take into account patient age and skeletal ... Feb 3, 2023 · slurred speech. stopping of menstrual bleeding. sudden loss of coordination. sudden, severe weakness or numbness in the arm or leg. sudden, unexplained shortness of breath. swelling of the fingers, hands, feet, or lower legs. troubled breathing at rest. unexpected or excess milk flow from the breasts. Mar 3, 2023 · Similar side effects of the pill vs. Depo-Provera injection. Both methods can cause tenderness or soreness in the breasts. Other side effects of oral contraceptives and the Depo-Provera shot include headaches and mood changes. Both methods can lead to a decreased interest in sex ( decreased libido) in some women. PIP: In Chiang Mai, Thailand, community physicians followed 2422 women who used the contraceptive injectable, Depo-Provera (DMPA), either during pregnancy and/or while breast feeding. They compared the longterm growth of the children exposed to DMPA with that of 1167 children who were not exposed to hormones during pregnancy or lactation. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. red skin lesions, often with a purple center. red, irritated eyes. sneezing. sore throat. sores, ulcers, or white spots in the mouth or on the lips. tightness in the chest. troubled breathing. unusual tiredness or weakness.Warning: Blood Pressure IncreasesTestosterone undecanoate can cause blood pressure (BP) increases that can increase the risk of major adverse cardiovascular events (MACE), including non-fatal myocardial infarction, non-fatal stroke and cardiovascular death.Effects on baby A small amount of the synthetic hormones in contraceptives will enter your milk, there is no evidence that this is dangerous to your baby. Some babies younger than six weeks may have difficulty metabolising the hormones and for this reason it is not recommended to start using a hormonal contraceptive until your baby is older. severe, sudden headache. shortness of breath. slurred speech. stopping of menstrual bleeding. sudden loss of coordination. sudden, severe weakness or numbness in the arm or leg. sudden, unexplained shortness of breath. swelling of the fingers, hands, feet, or lower legs. troubled breathing at rest.pounding in the ears. pressure in the stomach. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. seizures. sensation of spinning. severe or continuing stomach pain. slow growth in children. slow or fast heartbeat. sores, ulcers, or white spots on the lips or tongue or inside the mouth.You might notice: Uneven menstrual periods or no periods at all Headaches Nervousness Depression Dizziness Acne Changes in appetite Weight gain Unwanted facial and body hair Hair loss Loss of bone mineral density Belly pain Bloating Breakthrough bleeding Fatigue Less interest in sex Weakness ... There should be confidence in that." “The long-term side effects of COVID infection are a major concern. Up to 10 percent of people who have COVID experience side effects” such as difficulty thinking, pain, tiredness, loss of taste and depression. “We don’t know why that is, how long these symptoms will last or if there are effective ...After my very first injection 22 years ago, I have had zero periods and zero breakthrough bleeding. Zero side effects. Nothing. This has been a blessing. I had my last Depo Shot on 1/12/21. My next one is not due until 3/30/21. Today I wake up and have bleeding. Uses. Warnings: This medication may cause serious bone loss which may not return to normal after you stop using it. The risk of bone loss increases with longer use of this medication and smoking ...Jun 22, 2023 · People who had severe illness with COVID-19 might experience organ damage affecting the heart, kidneys, skin and brain. Inflammation and problems with the immune system can also happen. It isn't clear how long these effects might last. The effects also could lead to the development of new conditions, such as diabetes or a heart or nervous ... Hot flashes (flushing), increased sweating, night sweats, tiredness, headache, upset stomach, breast changes, acne, joint/muscle aches, trouble sleeping, reduced sexual interest, vaginal ... Very common (10% or more): Increase weight (up to 37%) Common (1% to 10%): Increased appetite, decreased appetite. Uncommon (0.1% to 1%): Diabetes mellitus exacerbated, hypercalcemia, fluid retention. Frequency not reported: Elevations of serum calcium and potassium levels, exacerbation of diabetes mellitus.Nov 24, 2017 · LousArk 24 Nov 2017. The Manufacturer recommends that you not use Depo Provera long term (more than 2 years), unless you have no option. In that case, you need to take the recommended breaks every couple of years. They state that it can take up to 18 months from the point you miss your shot, for your fertility to return. altered interest in having sexual intercourse. abnormal bleeding from the uterus. a problem with menstrual periods. dizziness. weight gain. headache. nervousness. reactions at the site of the ... Allergy shots are a form of treatment called immunotherapy. Each allergy shot contains a tiny amount of the specific substance or substances that trigger your allergic reactions. These are called allergens. Allergy shots contain just enough allergens to stimulate your immune system — but not enough to cause a full-blown allergic reaction.Spotting (light bleeding or brown discharge between periods) Not getting your period at all. About half of people stop getting their period while they’re on the shot (don’t worry, this is totally safe). Other possible side effects include: Nausea. Weight gain. Headaches. Sore breasts. Depression.Short-term side effects. Short-term side effects are those that we expect a cat to experience when initially placed on corticosteroids. These side effects depend both on the type of steroid prescribed and on the dosage administered and include: increased thirst and urination. increased hunger. general loss of energy. weakness or numbness in an arm or leg. pain in the arms, neck, back, or jaw. dizziness. faintness. If a doctor prescribes male testosterone injections to an adolescent to treat a constitutional ...Warning: Blood Pressure IncreasesTestosterone undecanoate can cause blood pressure (BP) increases that can increase the risk of major adverse cardiovascular events (MACE), including non-fatal myocardial infarction, non-fatal stroke and cardiovascular death.Nov 24, 2017 · LousArk 24 Nov 2017. The Manufacturer recommends that you not use Depo Provera long term (more than 2 years), unless you have no option. In that case, you need to take the recommended breaks every couple of years. They state that it can take up to 18 months from the point you miss your shot, for your fertility to return. Depo-Provera Vial Contraceptives. - Uses, Side Effects, This medication may cause serious bone loss which may not return to normal after you stop using it. The risk of bone loss increases with ... One major drawback of Depo-Provera is the continuous or irregular bleeding (spotting) that can sometimes occur during the first year. While this typically occurs during the first few months, it can persist for up to a year or longer for some people. Learn more about this side effect and what you can do if it persists. TEK IMAGE / Getty Images.redness of the skin. redness or swelling of the breast. sore on the skin of the breast that does not heal. swelling of the eyelids, face, fingers, lips, hands, feet, or lower legs. tightness in the chest. troubled breathing at rest. troubled breathing or swallowing. vaginal bleeding.Jun 22, 2023 · People who had severe illness with COVID-19 might experience organ damage affecting the heart, kidneys, skin and brain. Inflammation and problems with the immune system can also happen. It isn't clear how long these effects might last. The effects also could lead to the development of new conditions, such as diabetes or a heart or nervous ... Nov 24, 2017 · LousArk 24 Nov 2017. The Manufacturer recommends that you not use Depo Provera long term (more than 2 years), unless you have no option. In that case, you need to take the recommended breaks every couple of years. They state that it can take up to 18 months from the point you miss your shot, for your fertility to return. SU. suzanne66 7 March 2010. Chemical castration (as it is referred to in males) by using Depo-provera lowers testosterone and reduces sex drive. Males can have sexual intercourse but do not want to. It also discourages sexual fantasies and eradicates sexual obsessions. Mood changes and depression are reported side-effects of depo-provera.The most commonly reported side effects were hot flashes or sweats, gastrointestinal disorders, hyperhidrosis, edema, emotional lability or depression, respiratory disorder, urinary disorder, nausea or vomiting, injection site reaction, joint disorders, testicular atrophy, asthenia, flu syndrome, headache, skin reaction, fatigue, and pain.Forty-three subjects (37% of discontinuers) restarted Depo-Provera during the study period, with a mean time to restart of 8.4 months after the last Depo-Provera injection. Side effects were the main reported reason for Depo-Provera discontinuation, primarily menstrual irregularities (26%) and weight gain (18%).A person needs a Depo-Provera shot every 3 months to ensure it remains effective in preventing pregnancy. The birth control shot, or depo shot, Depo-Provera, or DMPA, is an injection that a person ...When To See a Healthcare Provider. Signs of pregnancy after Depo-Provera ( medroxyprogesterone ) may include missed period, nausea, breast tenderness, and more. Many people are able to get pregnant around 8 to 10 months after their last Depo-Provera shot. Depo-Provera, an injectable birth control method, is more than 99% effective at preventing ...Depo Medrol 80 MG Injection is used for treating Gout which is a type of joint inflammation. Sudden pain at night time and redness of the joints are few symptoms of Gout. Psoriasis. Depo Medrol 80 MG Injection is used to cure Psoriasis which is a type of skin disease. Itchy or sore patches and red skin are few symptoms of Psoriasis.Loss of bone density, if Lupron Depot is taken long term. Convulsions (violent shaking, seizures). Problems with your heart’s electrical activity, such as long QT syndrome .weakness or numbness in an arm or leg. pain in the arms, neck, back, or jaw. dizziness. faintness. If a doctor prescribes male testosterone injections to an adolescent to treat a constitutional ...Apr 13, 2023 · Summary. Commonly reported side effects of paliperidone include: akathisia, tachycardia, and drowsiness. Other side effects include: basal ganglia disease, dyskinesia, dystonia, orthostatic hypotension, postencephalitic parkinson's disease, sialorrhea, and prolonged qt interval on ecg. Continue reading for a comprehensive list of adverse effects. Methylprednisolone (Medrol) can cause changes in your fluids and electrolytes (e.g., sodium, potassium, and calcium). This can result in high blood pressure, swelling, and kidney problems. In addition, some studies suggest that methylprednisolone (Medrol) can damage the heart if used after a recent heart attack.redness of the skin. redness or swelling of the breast. sore on the skin of the breast that does not heal. swelling of the eyelids, face, fingers, lips, hands, feet, or lower legs. tightness in the chest. troubled breathing at rest. troubled breathing or swallowing. vaginal bleeding.Appropriate Use. The Depo-Provera birth control shot has advantages and disadvantages compared to other types of birth control. While it's convenient and effective, for example, the Depo shot also carries the risk of side effects like irregular bleeding and bone loss. This article looks at some of the pros and cons of using Depo-Provera.severe, sudden headache. shortness of breath. slurred speech. stopping of menstrual bleeding. sudden loss of coordination. sudden, severe weakness or numbness in the arm or leg. sudden, unexplained shortness of breath. swelling of the fingers, hands, feet, or lower legs. troubled breathing at rest.So I have been on depo for about two years now and have never had severe problems. I have noticed since starting Depo that I have more vaginal discharge, more acne, and my boobs tend to be sore more often. However, this past week I have noticed an intense increase in some side effects. My boobs are extremely sore and I am having a mixture of ...May 15, 2002 · In fact, women frequently discontinue hormonal contraception because of irregular bleeding and other side effects. 1 – 3 One study 4 found that 32 percent of 1,657 women who started taking oral ... The shots may be doing more harm than good. In a new study published in the journal Radiology, researchers looked at 459 patients in a US hospital who had received one to three corticosteroid ...weakness near the injection site; Long-term side effects. Taking steroid shots for a prolonged period of time increases the risk of more serious side effects. Long-term side effects can include:In fact, women frequently discontinue hormonal contraception because of irregular bleeding and other side effects. 1 – 3 One study 4 found that 32 percent of 1,657 women who started taking oral ...pain, tenderness, or swelling of the foot or leg. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. severe, sudden headache. shortness of breath. slurred speech. stopping of menstrual bleeding. sudden loss of coordination. sudden, severe weakness or numbness in the arm or leg.LousArk 24 Nov 2017. The Manufacturer recommends that you not use Depo Provera long term (more than 2 years), unless you have no option. In that case, you need to take the recommended breaks every couple of years. They state that it can take up to 18 months from the point you miss your shot, for your fertility to return.
Aug 9, 2023 · Depo-Provera use may also delay the return of your fertility. About 50% of women will be able to get pregnant within 10 months after their last Depo-Provera injection, but it can take up to 18 months for fertility to return. Some women report irregular or continuous bleeding when using Depo-Provera along with other unwanted side effects. . Alpha triplets mate pdf
A further benefit of depot treatment is the achievement of stable plasma concentrations over long periods, allowing injections to be given every few weeks. However, this also represents a potential disadvantage in that there is a lack of flexibility of administration. Should adverse effects develop, the drug cannot be rapidly withdrawn.A depot injection is a slow-release form of medication. The injection uses a liquid that releases the medication slowly, so it lasts a lot longer. Depot injections can be used for various types of drug, including some antipsychotics. The medication used in depot injections is the same as other forms of the drug, such as tablets or liquid. Common side effects may include: weight gain (especially in your face or your upper back and torso); slow wound healing; muscle pain or weakness; thinning skin, increased sweating; stomach ...A depot injection is a slow-release form of medication. The injection uses a liquid that releases the medication slowly, so it lasts a lot longer. Depot injections can be used for various types of drug, including some antipsychotics. The medication used in depot injections is the same as other forms of the drug, such as tablets or liquid.Feb 22, 2022 · They might include: Abdominal pain Bloating Decreased interest in sex Depression Dizziness Headaches Irregular periods and breakthrough bleeding Nervousness Weakness and fatigue Weight gain When To See a Healthcare Provider. Signs of pregnancy after Depo-Provera ( medroxyprogesterone ) may include missed period, nausea, breast tenderness, and more. Many people are able to get pregnant around 8 to 10 months after their last Depo-Provera shot. Depo-Provera, an injectable birth control method, is more than 99% effective at preventing ...Methylprednisolone (Medrol) can cause changes in your fluids and electrolytes (e.g., sodium, potassium, and calcium). This can result in high blood pressure, swelling, and kidney problems. In addition, some studies suggest that methylprednisolone (Medrol) can damage the heart if used after a recent heart attack.The most commonly reported side effects were hot flashes or sweats, gastrointestinal disorders, hyperhidrosis, edema, emotional lability or depression, respiratory disorder, urinary disorder, nausea or vomiting, injection site reaction, joint disorders, testicular atrophy, asthenia, flu syndrome, headache, skin reaction, fatigue, and pain.Long-term case-controlled surveillance of users of Depo-Provera CI found no overall increased risk of ovarian or liver cancer. 5.4 Ectopic Pregnancy Be alert to the possibility of an ectopic pregnancy among women using Depo-Provera CI who become pregnant or complain of severe abdominal pain.In many cases, unwanted effects of the Mirena IUD are not long-term. According to Planned Parenthood, common side effects such as spotting between periods and cramping typically get better in 3 ...DEPO-MEDROL is an anti-inflammatory glucocorticoid for intramuscular, intra-articular, soft tissue, or intralesional injection. It is available in three strengths: 20 mg/mL, 40 mg/mL, 80 mg/mL. Sodium Chloride was added to adjust tonicity. When necessary, pH was adjusted with sodium hydroxide and/or hydrochloric acid.You might notice: Uneven menstrual periods or no periods at all Headaches Nervousness Depression Dizziness Acne Changes in appetite Weight gain Unwanted facial and body hair Hair loss Loss of bone mineral density Belly pain Bloating Breakthrough bleeding Fatigue Less interest in sex Weakness ... Hot flashes (flushing), increased sweating, night sweats, tiredness, headache, upset stomach, breast changes, acne, joint/muscle aches, trouble sleeping, reduced sexual interest, vaginal ...Depo Provera (Depo medroxyprogesterone Acetate or DMPA) is a long acting progestin given by intramuscular injection every 12 weeks. It has been approved for contraception in the USA since 1992, but has been available in some countries since the 1960s. It is important to understand the benefits, risks and side effects, and to consider One major drawback of Depo-Provera is the continuous or irregular bleeding (spotting) that can sometimes occur during the first year. While this typically occurs during the first few months, it can persist for up to a year or longer for some people. Learn more about this side effect and what you can do if it persists. TEK IMAGE / Getty Images.puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. red skin lesions, often with a purple center. red, irritated eyes. sneezing. sore throat. sores, ulcers, or white spots in the mouth or on the lips. tightness in the chest. troubled breathing. unusual tiredness or weakness.puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. red skin lesions, often with a purple center. red, irritated eyes. sneezing. sore throat. sores, ulcers, or white spots in the mouth or on the lips. tightness in the chest. troubled breathing. unusual tiredness or weakness..